Humans are unreliable models of mouse disease

XzetaU8 | 198 points | 7mon ago | www.cell.com

computerdork|7mon ago

Does anyone have a link to the non-paywalled full-text?

RateMyPE|7mon ago

I'm not going to link the exact page because I'm not sure if it's allowed, but if you go to this Reddit post: https://www.reddit.com/r/scihub/comments/1g89i9z/best_altern...

And click on the link from the top comment, you can search for the article using the DOI code which is: 10.1016/j.cell.2024.08.006

ag8|7mon ago

Yeah, I'm a bit surprised that this has so many upvotes without any easily accessible text

dang|7mon ago

Unfortunately it was probably just a shallow reaction to the admittedly witty title. I've downweighted the post now, in keeping with https://news.ycombinator.com/newsfaq.html and https://news.ycombinator.com/item?id=10178989. If someone comes up with a workaround, we can restore the thread.

RateMyPE|7mon ago

I've posted another comment on this parent comment saying how you could access the full-text, but I haven't directly posted the link to said text, as I'm not sure if it's allowed.

hprotagonist|7mon ago

The first — and maybe only, or at least sufficient — use of tissue engineering at scale is not going to be growing organs for implantation, growing meat in a lab for human consumption, or anything quite that flashy.

The first one is going to be the ability to grow liver slices at scale for tox screening in pharma.

animal rights issues entirely aside: we spend entirely too much time and money killing a whole lot of mice all the while knowing perfectly well they’re barely semi-decent models for toxicology.

if I can fill the lab with constant flow vats of slices of liver, they’ll read out fast, they’ll be a massive savings in time and money, and they’ll give us much more accurate results.

bflesch|7mon ago

Sounds like a worthwhile undertaking. Do you know someone who is actively working on this problem?

shadowgovt|7mon ago

The research has been complicated in the US because so many of the cell lines pass through fetal tissue. But IIUC it's ongoing (and not so encumbered in other countries). Not to say all are intertwined with fetal cell research, only that it's one of the cheapest sources of stem cells and law has made using it complicated.

RangerScience|7mon ago

Do you (or a GP) know how I can donate already-extracted stem cells for this?

lukan|7mon ago

Many are, it is just not a trivial problem to create or copy living organs.

MattGaiser|7mon ago

It it meaningfully easier than growing livers for transplantation?

thereisnospork|7mon ago

Almost definitely: livers to implant need to be full sized and last years to decades. A test liver could be 1cm2, fit on a microscope slide, and have a two week shelf life.

Not to mention that there is a much higher bar, ethically, regulatorily, and economically for testing a synthetic implantable liver vs a 'liver-on-a-chip'.